Synthesis and evaluation of anti-oxidant and cytotoxic activities of novel 10-undecenoic acid methyl ester based lipoconjugates of phenolic acids

• Naganna Narra,
• Shiva Shanker Kaki,
• Rachapudi Badari Narayana Prasad,
• Sunil Misra,
• Koude Dhevendar,
• Venkateshwarlu Kontham and
• Padmaja V. Korlipara

Beilstein J. Org. Chem. 2017, 13, 26–32, doi:10.3762/bjoc.13.4

• calorimetry (DSC). The prepared compounds were also screened for their cytotoxic activity against five cell lines. It was observed that the lipoconjugates of caffeic acid, sinapic acid, ferulic acid, and coumaric acid displayed anticancer and anti-oxidant properties. The anticancer properties of these

• derivatives have been assessed by their IC50 inhibitory values in the proliferation of MDA-MB231, SKOV3, MCF7, DU 145 and HepG2 cancer cell lines. Keywords: anticancer; anti-oxidants; caffeic acid; coumaric acid; ferulic acid; phenolic lipids; sinapic acid; undecenoic acid; Introduction Phenolic compounds

• showed interesting activity. Experimental Materials 10-Undecenoic acid, 1,1’-azobis(cyclohexanecarbonitrile) (ABCN), hydroxybenzotriazole (HOBt) and 1-ethyl-3-(3’-dimethylaminopropyl)carbodiimide hydrochloride (EDC·HCl), cysteamine hydrochloride, cinnamic acid, sinapic acid, ferulic acid, p-coumaric acid